Cl-943, a potential antipsychotic agent. III. Evaluation of effects on dopamine neuronal activity

Cl-943 (8-ethyl-7,8-dihydro-1,3,5-trimethyl-1 H-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine) has been identified as a novel potential antipsychotic agent that does not bind to dopamine (DA) receptors. In the present studies, the effects of acute and chronic administration of Cl-943 on the electrophysiol...

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Published inThe Journal of pharmacology and experimental therapeutics Vol. 251; no. 1; pp. 123 - 130
Main Authors Meltzer, L T, Christoffersen, CL, Heffner, T G, Freeman, A S, Chiodo, LA
Format Journal Article
LanguageEnglish
Published 01.01.1989
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Summary:Cl-943 (8-ethyl-7,8-dihydro-1,3,5-trimethyl-1 H-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine) has been identified as a novel potential antipsychotic agent that does not bind to dopamine (DA) receptors. In the present studies, the effects of acute and chronic administration of Cl-943 on the electrophysiological activity of A9 and A10 DA neurons were assessed and compared to the effects of DA antagonist antipsychotic drugs. In this series of electro-physiological studies, Cl-943 did not produce effects indicative of DA receptor antagonism. These data support the hypothesis that Cl-943 produces its preclinical antipsychotic-like behavioral effects by a mechanism other than DA receptor antagonism.
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ISSN:0022-3565