Characterization of the binding of ( super(3)H)L-365,260: A new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand

( super(3)H)L-365, 260, ((3R-(+)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin- 3-yl)-N'-(3-methylphenyl)urea), a new potent and selective nonpeptide brain cholecystokinin (CCK-B) and gastrin receptor antagonist, bound saturably and reversibly to guinea pig brain membranes. Scatchard...

Full description

Saved in:
Bibliographic Details
Published inMolecular pharmacology Vol. 35; no. 6; pp. 803 - 808
Main Authors Chang, RSL, Chen, T B, Bock, M G, Freidinger, R M, Chen, R, Rosegay, A, Lotti, V J
Format Journal Article
LanguageEnglish
Published 01.01.1989
Online AccessGet full text

Cover

More Information
Summary:( super(3)H)L-365, 260, ((3R-(+)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin- 3-yl)-N'-(3-methylphenyl)urea), a new potent and selective nonpeptide brain cholecystokinin (CCK-B) and gastrin receptor antagonist, bound saturably and reversibly to guinea pig brain membranes. Scatchard analysis indicated a single class of high affinity binding sites. The data indicates that ( super(3)H)L-365,260 represents a new potent nonpeptide antagonist radioligand suitable for the study of brain CCK-B and gastrin receptors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0026-895X