Comparative localization of murine monoclonal antibody Mel-14 F(ab') sub(2) fragment and whole IgG2a in human glioma xenografts

Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to normal tissues. In this study, the authors hav...

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Published inCancer research (Chicago, Ill.) Vol. 48; no. 20; pp. 5701 - 5707
Main Authors Colapinto, E V, Humphrey, P A, Zalutsky, M R, Groothuis, DR, Friedman, H S, de Tribolet, N, Carrel, S, Bigner, D D
Format Journal Article
LanguageEnglish
Published 01.01.1988
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Summary:Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to normal tissues. In this study, the authors have examined the in vivo localization of radioiodinated MAb Mel-14, a murine immunoglobulin G2a (IgG2a) reactive with gliomas, and its F(ab') sub(2) fragment in s.c. and intracranial xenografts of human glioma cell line D-54 MG in athymic mice. These studies demonstrate that the F(ab') sub(2) fragment of Mel-14 may be a potential agent for immune-directed brain tumor diagnosis and therapy.
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ISSN:0008-5472