Plasmapheresis for late-stage trypanosomiasis

The authors describe an 18-year-old Angolan woman who had lived for 18 months in Rome and was admitted to the hospital in April, 1988. With the hypothesis that the clinical features were being caused by the deposition of immune complexes in the brain and vessels plasmapheresis with cascade filtratio...

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Published inThe Lancet (North American edition) Vol. 1; no. 8648; p. 1200
Main Authors Spinazzola, F, D'Amato, C, De Felici, A, Giannuzzi, R, Paglia, M G, Struglia, C, Tocci, G, Visco, G, Galgani, S, Cotroneo, E
Format Journal Article
LanguageEnglish
Published 01.01.1989
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Summary:The authors describe an 18-year-old Angolan woman who had lived for 18 months in Rome and was admitted to the hospital in April, 1988. With the hypothesis that the clinical features were being caused by the deposition of immune complexes in the brain and vessels plasmapheresis with cascade filtration was started on the 15th day of antiparasitic therapy. Plasmapheresis was done five times over 10 days, while DFMO administration was continued. One volume of plasma was exchanged in 3 h. Plasmapheresis was well tolerated and the neurological picture improved rapidly. On day 1 the patient awoke briefly and by day 5 she was conscious. On day 7 her tremor became less intense and on day 10 she regained sphincter control.
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ISSN:0099-5355