High-affinity Ca super(2+)-binding site inhibiting Ca super(2+) release from sarcoplasmic reticulum

Ca super(2+) release from sarcoplasmic reticulum membranes, activated by alkaline pH occurs only when EGTA is present in the release medium. Addition of very low concentrations of Ca super(2+) to the medium inhibits Ca super(2+) release. We suggest the involvement of high-affinity Ca super(2+)-bindi...

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Bibliographic Details
Published inFEBS letters Vol. 243; no. 1; pp. 88 - 92
Main Authors Argaman, A, Shoshan-Barmatz, V
Format Journal Article
LanguageEnglish
Published 01.01.1989
Subjects
sarcoplasmic reticulum
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Summary:Ca super(2+) release from sarcoplasmic reticulum membranes, activated by alkaline pH occurs only when EGTA is present in the release medium. Addition of very low concentrations of Ca super(2+) to the medium inhibits Ca super(2+) release. We suggest the involvement of high-affinity Ca super(2+)-binding sites in the control of Ca super(2+) release.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0014-5793