Effects of different anti - HIV therapies on progression of hepatitis C in HCV/HIV - coinfected patients

The objective of this study is to investigate the effect of protease inhibitors (PIs)-or non-nucleoside reverse transcriptase inhibitors (NNRTIs)-based therapy on the progression of hepatitis C in patients with hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection. A total of 273 pa...

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Published inLinchuang gandanbing zazhi Vol. 29; no. 11; pp. 835 - 838
Main Authors SUN, Hongqing, HUANG, Qin, SHEN, Fang
Format Journal Article
LanguageEnglish
Published 01.11.2013
Subjects
Hepatitis C virus
Human immunodeficiency virus
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Summary:The objective of this study is to investigate the effect of protease inhibitors (PIs)-or non-nucleoside reverse transcriptase inhibitors (NNRTIs)-based therapy on the progression of hepatitis C in patients with hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfection. A total of 273 patients initially diagnosed with HCV/HIV coinfection were enrolled and divided into PIs group (n = 135) and NNRTIs group (n = 138) to receive PIs-based therapy and NNRTIs-based therapy, respectively, for one year. The obtained data were analyzed using SPSS 11. 5 software; enumeration data were analyzed using the Kolmogorov-Smirnov test, and non-normal data were analyzed using the Mann-Whitney U test. NNRTIs-based therapy can accelerate the progression of hepatitis C in HCV/HIV-coinfected patients.
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ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2013.11.009