Isolation and characterization of the human thyrotropin beta -subunit gene. Difference in gene structure and promoter function from murine species

The human thyrotropin beta -subunit gene was isolated and characterized from two genomic libraries and found to contain three exons separated by two introns of 3.9 and 0.45 kilobase pairs. Exons 2 and 3 in the mouse thyrotropin beta -subunit gene are not found in humans due to a lack of consensus se...

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Published inThe Journal of biological chemistry Vol. 263; no. 25; pp. 12538 - 12542
Main Authors Wondisfore, F E, Radovick, S, Moates, J M, Usala, S J, Weintraub, B D
Format Journal Article
LanguageEnglish
Published 01.01.1988
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Summary:The human thyrotropin beta -subunit gene was isolated and characterized from two genomic libraries and found to contain three exons separated by two introns of 3.9 and 0.45 kilobase pairs. Exons 2 and 3 in the mouse thyrotropin beta -subunit gene are not found in humans due to a lack of consensus sequences important in exon splicing.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0021-9258