Peptide and protein synthesis by segment synthesis-condensation

In this article the authors describe efforts in their laboratory to prepare models for biologically active peptides and polypeptides in which they have focused their attention on secondary structural elements such as alpha helices and have, to a first approximation, been able to neglect tertiary str...

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Published inScience (American Association for the Advancement of Science) Vol. 243; no. 4888; pp. 187 - 192
Main Authors Kaiser, E T, Mihara, H, Laforet, G A, Kelly, J W, Walters, L, Findeis, MA, Sasaki, T
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
peptide synthesis
proteins
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Summary:In this article the authors describe efforts in their laboratory to prepare models for biologically active peptides and polypeptides in which they have focused their attention on secondary structural elements such as alpha helices and have, to a first approximation, been able to neglect tertiary structure. They then proceed to the question of whether the principles that they have developed for the design of secondary structural units in such molecules can be extended to the replacement of naturally occurring secondary structural elements by redesigned units in proteins where folding to form tertiary structures is crucial.
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ISSN:0036-8075