Phospholipase A sub(2) activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-Formyl-Met-Leu-Phe

Both 1,2-diacyl- and 1-O-alkyl-2-acylglycerols are formed during stimulation of human neutrophils (PMN), and both can prime respiratory burst responses for stimulation by the chemotactic peptide, N-formyl-Met-Leu-Phe (fMLP); however, mechanisms of priming are unknown. Arachidonic acid (AA) release t...

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Published inThe Journal of biological chemistry Vol. 263; no. 32; pp. 16787 - 16795
Main Authors Bauldry, SA, Wykle, R L, Bass, DA
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
alkylacylglycerol
diacylglycerol
leukocytes (neutrophilic)
phospholipase A2
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Summary:Both 1,2-diacyl- and 1-O-alkyl-2-acylglycerols are formed during stimulation of human neutrophils (PMN), and both can prime respiratory burst responses for stimulation by the chemotactic peptide, N-formyl-Met-Leu-Phe (fMLP); however, mechanisms of priming are unknown. Arachidonic acid (AA) release through phospholipase A sub(2) activation and metabolism by 5-lipoxygenase are important activities of PMN during inflammation and could be involved in the process of primed stimulation. Therefore, the authors have examined the ability of diacyl- and alkylacylglycerols to act as priming agents for AA release and metabolism in human neutrophils.
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ISSN:0021-9258