Quinolones and multiresistant Plasmodium falciparum

The authors have tested ciprofloxacin, by the 48 h super(3)H-hypoxanthine incorporation technique agaists a Thai multiresistant line of the parasite. The inhibitory concentration (IC) of ciprofloxacin observed was 5.2 mu g/ml, similar to the 8 mu g/ml reported previously. This indicates that the 4-q...

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Published inThe Lancet (North American edition) Vol. 2; no. 8605; p. 281
Main Authors Midgley, J M, Keter, D W, Phillipson, J D, Grant, S, Warhurst, D C
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
Plasmodium falciparum
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Summary:The authors have tested ciprofloxacin, by the 48 h super(3)H-hypoxanthine incorporation technique agaists a Thai multiresistant line of the parasite. The inhibitory concentration (IC) of ciprofloxacin observed was 5.2 mu g/ml, similar to the 8 mu g/ml reported previously. This indicates that the 4-quinolones are of potential interest in combating the spread of chloroquine-resistant malaria. The authors have also studied the activity of other 4-quinolones against the K1 chloroquine, sulphadoxine, and pyrimethamine resistant P. falciparum) strain (IC50 in mu g/ml). It seems that a fluorine atom in position 6, together with a basic substituent at C7 on a quinolone (rather than a 1,8-naphthyridone) nucleus are associated with antimalarial activity.
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ISSN:0099-5355