Activation of Na super(+)/H super(+) exchange and the expression of cellular proto-oncogenes in mitogen- and phorbol ester-treated lymphocytes

It has been suggested that an intracellular alkalinization, resulting from stimulation of Na super(+)/H super(+) exchange, is a necessary step and perhaps the signal leading to cellular proliferation in cells stimulated by mitogens. This hypothesis was tested by measuring the early stages of the pro...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 263; no. 18; pp. 8658 - 8665
Main Authors Grinstein, S, Smith, J D, Onizuka, R, Cheung, R K, Gelfand, E W, Benedict, S
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
antiport
cell proliferation
lymphocytes
protons
sodium
Online AccessGet full text

Cover

More Information
Summary:It has been suggested that an intracellular alkalinization, resulting from stimulation of Na super(+)/H super(+) exchange, is a necessary step and perhaps the signal leading to cellular proliferation in cells stimulated by mitogens. This hypothesis was tested by measuring the early stages of the proliferative cascade in cells where antiport activity was precluded. It was concluded that the stimulation of the Na super(+)/H super(+) antiport that accompanies the addition of mitogens is neither sufficient nor necessary for the initiation of cellular proliferation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0021-9258