Dicyclohexyl-carbodiimide interaction with sarcoplasmic reticulum: Inhibition of Ca super(2+) efflux

Dicyclohexyl-carbodiimide (DCCD), a hydrophobic carboxyl reagent, inhibited Ca super(2+) release from Ca super(2+)-loaded sarcoplasmic reticulum vesicles. The authors suggest that a carboxyl residue(s), located in a hydrophobic region of a protein(s), is involved in the control of Ca super(2+) relea...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 263; no. 13; pp. 6315 - 6321
Main Authors Argaman, A, Shoshan-Barmatz, V
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
calcium
dicyclohexylcarbodiimide
sarcoplasmic reticulum
skeletal muscle
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Summary:Dicyclohexyl-carbodiimide (DCCD), a hydrophobic carboxyl reagent, inhibited Ca super(2+) release from Ca super(2+)-loaded sarcoplasmic reticulum vesicles. The authors suggest that a carboxyl residue(s), located in a hydrophobic region of a protein(s), is involved in the control of Ca super(2+) release, where DCCD interaction with this group blocks Ca super(2+) release. The involvement of one or all of the DCCD-labeled proteins in Ca super(2+) release and ryanodine binding is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0021-9258