Somatostatin pretreatment increases the number of somatostatin receptors in GH sub(4)C sub(1) pituitary cells and does not reduce cellular responsiveness to somatostatin

The authors examined the effects of chronic somatostatin (SRIF) pretreatment on the subsequent ability of GH sub(4)C sub(1) pituitary cell line to bind and respond to this hormone. The observation that chronic SRIF exposure did not cause homologous desensitization in GH sub(4)C sub(1) cells and incr...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 263; no. 2; pp. 714 - 721
Main Authors Presky, D H, Schonbrunn, A
Format Journal Article
LanguageEnglish
Published 01.01.1988
Subjects
pituitary
somatostatin
Online AccessGet full text

Cover

More Information
Summary:The authors examined the effects of chronic somatostatin (SRIF) pretreatment on the subsequent ability of GH sub(4)C sub(1) pituitary cell line to bind and respond to this hormone. The observation that chronic SRIF exposure did not cause homologous desensitization in GH sub(4)C sub(1) cells and increased rather than decreased SRIF receptor number is consistent with the fact that this neuropeptide is not rapidly internalized by receptor-mediated endocytosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0021-9258