Organization of the gene encoding the human beta -hexosaminidase alpha -chain
The authors have characterized the intron-exon organization of the human beta -hexosaminidase alpha -chain gene. The cloned genomic DNA was analyzed by restriction endonuclease mapping, Southern blotting, and DNA sequencing. It was determined that the alpha -chain gene is similar to 35 kilobases lon...
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| Published in | The Journal of biological chemistry Vol. 262; no. 12; pp. 6577 - 5681 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.1987
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| Online Access | Get full text |
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| Summary: | The authors have characterized the intron-exon organization of the human beta -hexosaminidase alpha -chain gene. The cloned genomic DNA was analyzed by restriction endonuclease mapping, Southern blotting, and DNA sequencing. It was determined that the alpha -chain gene is similar to 35 kilobases long and is split into 14 exons. Differential transcription or processing of the most 3' exon of the gene results in two alpha -chain mRNAs with different 3'-untranslated regions. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0021-9258 |