The chronic administration of dopamine antagonists and methamphetamine changed the ( super(3)H)-cholecystokinin-8 binding sites in the rat frontal cortex

The specific cholecystokinin (CCK) binding in the slide-mounted tissue sections of the rat frontal cortex was measured with ( super(3)H)-CCK-8. The chronic administration of dopamine (DA) antagonists and methamphetamine (MAP) showed a tendency to increase the ( super(3)H)-CCK-8 binding sites (Bmax)...

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Published inNeuropeptides (Edinburgh) Vol. 10; no. 3; pp. 221 - 225
Main Authors Fukamauchi, F, Yoshikawa, T, Kaneno, S, Shibuya, H, Takahashi, R
Format Journal Article
LanguageEnglish
Published 01.01.1987
Subjects
cholecystokinin octapeptide
cortex (frontal)
dopamine
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Summary:The specific cholecystokinin (CCK) binding in the slide-mounted tissue sections of the rat frontal cortex was measured with ( super(3)H)-CCK-8. The chronic administration of dopamine (DA) antagonists and methamphetamine (MAP) showed a tendency to increase the ( super(3)H)-CCK-8 binding sites (Bmax) in the frontal cortex. Long-term treatments with DA antagonists led to the depletion of CCK-8 and may have caused an observed proliferation of CCK-8 receptors in the frontal cortex.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0143-4179