(D-Ala super(2),(F sub(5))Phe super(4))-dynorphin sub(1-13)-NH sub(2) (DAFPHEDYN): A potent analog of dynorphin 1-13

• Published in: Peptides (New York, N.Y. : 1980) Vol. 8; no. 5; pp. 811 - 817
• Main Authors: Walker, J M, Coy, D H, Young, E A, Baldrighi, G, Siegel, S F, Bowen, W D, Akil, H
• Format: Journal Article
• Language: English
• Published: 01.01.1987
• ISSN: 0196-9781

Intracerebroventricular administration of the dynorphin analog, (D-Ala super(2),(F sub(5))Phe super(4))-dynorphin sub(1-13)-NH sub(2) (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of naltrexone or naloxone. DAFPHEDYN retains the same degree of Kappa selectivity as the parent compound (dynorphin 1-13) though a drop in affinity occurred. DAFPHEDYN may be of significant interest because it retains the essential pharmacology of the parent compound and exhibits marked in vivo potency.