Molecular mapping of murine I region recombinants. II. Crossing over in the E sub( beta ) gene is restricted to a 4.5 KB stretch of DNA that excludes the beta 1 exon

The crossing over in five murine I-region recombinants (I super(s)/I super(k)) was studied by restriction fragment length polymorphism analysis after Southern blot hybridization by using I-region-specific probes. The findings imply that the I-E molecules expressed in these recombinants will probably...

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Published inThe Journal of immunology (1950) Vol. 137; no. 12; pp. 4004 - 4009
Main Authors Saha, B K, Raziuddin, Cullen, SE
Format Journal Article
LanguageEnglish
Published 01.01.1986
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Summary:The crossing over in five murine I-region recombinants (I super(s)/I super(k)) was studied by restriction fragment length polymorphism analysis after Southern blot hybridization by using I-region-specific probes. The findings imply that the I-E molecules expressed in these recombinants will probably have conserved sequences and therefore will exhibit identical I-E-restricted immune responses, despite the fact that crossing over could have occurred at different sites within the beta 1- beta 2 intron.
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ISSN:0022-1767