Inactivation of Antieoplastics in Clinical Wastewater by Electrolysis

Electrolysis was evaluated for inactivating epirubicin hydrochloride (EH) in solution, which is used widely in Japan for the treatment of selected cancers. The process was also applied to a mixture of antineoplastics under optimal conditions. The minimum inhibitory concentrations of the chemicals we...

Full description

Saved in:
Bibliographic Details
Published inChemosphere (Oxford) Vol. 60; no. 8; p. 1018
Main Authors Hirose, Jun, Kondo, Fumitake, Nakano, Takashi, Kobayashi, Toyohide, Hiro, Naoki, Ando, Yoko, Takenaka, Hiroshi
Format Journal Article
LanguageEnglish
Published 01.08.2005
Online AccessGet full text

Cover

More Information
Summary:Electrolysis was evaluated for inactivating epirubicin hydrochloride (EH) in solution, which is used widely in Japan for the treatment of selected cancers. The process was also applied to a mixture of antineoplastics under optimal conditions. The minimum inhibitory concentrations of the chemicals were measured according to the microdilution method, which is outlined, and cytotoxicity and mutagenicity were assayed. Results showed that electrolysis degraded EH and eliminated its cytotoxicity and mutagenicity, and similar results were obtained for the mixture of antineoplastics, which included: irinotecan hydrochloride, vincristine sulfate, mitomycin C, paclitaxel, methotrexate, and cisplatin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0045-6535