Pharmacokinetics and plasma bactericidal activity of aztreonam in low-birth-weieight infants
Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma concentration-time curves were measured on two occasions. The mean peak plasma concentrations at completion of the 10-min infusion were from 65 to 83...
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| Published in | Antimicrobial agents and chemotherapy Vol. 31; no. 1; pp. 81 - 83 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.1987
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma concentration-time curves were measured on two occasions. The mean peak plasma concentrations at completion of the 10-min infusion were from 65 to 83 mu g/ml, the higher concentrations being seen in the larger infants. The median peak and trough plasma bactericidal titer against a strain of Escherichia coli was 1:16. Against a strain of Pseudomonas aeruginosa , the median peak and trough bactericidal titers were 1:8 to 1:16 and 1:4, respectively. |
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| AbstractList | Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma concentration-time curves were measured on two occasions. The mean peak plasma concentrations at completion of the 10-min infusion were from 65 to 83 mu g/ml, the higher concentrations being seen in the larger infants. The median peak and trough plasma bactericidal titer against a strain of Escherichia coli was 1:16. Against a strain of Pseudomonas aeruginosa , the median peak and trough bactericidal titers were 1:8 to 1:16 and 1:4, respectively. |
| Author | Likitnukul, S Olsen, K Threlkeld, N Darabi, A McCracken, GH Jr |
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| Snippet | Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma... |
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| SubjectTerms | Escherichia coli Pseudomonas aeruginosa |
| Title | Pharmacokinetics and plasma bactericidal activity of aztreonam in low-birth-weieight infants |
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