Pharmacokinetics and plasma bactericidal activity of aztreonam in low-birth-weieight infants

Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma concentration-time curves were measured on two occasions. The mean peak plasma concentrations at completion of the 10-min infusion were from 65 to 83...

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Published inAntimicrobial agents and chemotherapy Vol. 31; no. 1; pp. 81 - 83
Main Authors Likitnukul, S, McCracken, GH Jr, Threlkeld, N, Darabi, A, Olsen, K
Format Journal Article
LanguageEnglish
Published 01.01.1987
Subjects
Escherichia coli
Pseudomonas aeruginosa
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Summary:Aztreonam was administered intravenously every 12 h during week 1 and every 8 h during weeks 2 to 4 of life to 26 low-birth-weight infants, and plasma concentration-time curves were measured on two occasions. The mean peak plasma concentrations at completion of the 10-min infusion were from 65 to 83 mu g/ml, the higher concentrations being seen in the larger infants. The median peak and trough plasma bactericidal titer against a strain of Escherichia coli was 1:16. Against a strain of Pseudomonas aeruginosa , the median peak and trough bactericidal titers were 1:8 to 1:16 and 1:4, respectively.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0066-4804