env -Encoded residues are not required for transformation by p48 super(v-myb)

The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48 super(v-myb), is partially encoded by the retrovial gag and env genes. The authors demonstrated that the env -encode...

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Bibliographic Details
Published inJournal of virology Vol. 61; no. 3; pp. 933 - 936
Main Authors Lipsick, J S, Ibanez, CE
Format Journal Article
LanguageEnglish
Published 01.01.1987
Subjects
avian myeloblastosis virus
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Summary:The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48 super(v-myb), is partially encoded by the retrovial gag and env genes. The authors demonstrated that the env -encoded carboxyl terminus of p48 super(v-myb) is not required for transformation. The results showed, in addition, that a coding region of c-myb which is not essential for transformation was transduced by avian myeloblastosis virus.
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ISSN:0022-538X