Long-term modulation of Ca super(2+)-stimulated autophosphorylation and subcellular distribution of the Ca super(2+)/calmodulin-dependent protein kinase in the brain of Drosophila

After prolonged visual adaptation of Drosophila , dramatic long-term changes of in vitro phosphorylation of a 50-kDa brain protein that is identical to the Ca super(2+)/calmodulin-dependent protein kinase can be measured in isolated heads. By selective receptor cell desensitization in blue light, su...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 83; no. 24; pp. 9789 - 9793
Main Authors Willmund, R, Mitschulat, H, Schneider, K
Format Journal Article
LanguageEnglish
Published 01.01.1986
Subjects
brain
calcium
calmodulin
Drosophila
Drosophilidae
protein kinase
Online AccessGet full text

Cover

More Information
Summary:After prolonged visual adaptation of Drosophila , dramatic long-term changes of in vitro phosphorylation of a 50-kDa brain protein that is identical to the Ca super(2+)/calmodulin-dependent protein kinase can be measured in isolated heads. By selective receptor cell desensitization in blue light, subcellular distribution of the 50-kDa kinase in fly brain is modified, and Ca super(2+)-stimulated in vitro phosphorylation is increased. Concomitantly the 50-kDa kinase is translocated by in vitro phosphorylation from the membrane cytoskeleton complex into the cytoplasm. After adaptation, association of the enzyme to the membrane shows long-term modification. The authors propose that Ca super(2+)/calmodulin-dependent kinase II is involved in long-term modulation of synaptic transmission.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0027-8424