Diversin, from Ferula diversivittata protects human lymphocytes against oxidative stress induced by H sub(2)O sub(2)

In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 mu M) alone, or in the p...

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Published inNatural product research Vol. 27; no. 11; pp. 1016 - 1019
Main Authors Zarei, Hassan, Rezaee, Ramin, Behravan, Effat, Soltani, Fatemeh, Mosaffa, Fatemeh, Iranshahi, Mehrdad, Behravan, Javad
Format Journal Article
LanguageEnglish
Published 01.06.2013
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Summary:In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 mu M) alone, or in the presence of H sub(2)O sub(2) (25 mu M). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 mu M) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H sub(2)O sub(2).
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2012.688053