Transfer and distribution of accumulated ( super(14)C)polychlorinated biphenyls from maternal to fetal and suckling rats

• Published in: Archives of environmental contamination and toxicology Vol. 15; no. 6; pp. 709 - 715
• Main Authors: Takagi, Y, Aburada, S, Hashimoto, K, Kitaura, T
• Format: Journal Article
• Language: English
• Published: 01.01.1986
• ISSN: 0090-4341

( super(14)C)polychlorinated biphenyls (PCBs (KC-600)) were administered orally to female rats at the dose of 10 mg/kg in olive oil once a week for five weeks. Four weeks after the last administration of ( super(14)C)PCBs, they were mated with untreated males. The distribution of total super(14)C was examined in maternal and offspring tissues. The average amount of PCBs accumulated dams was 44.2% of the dose two weeks after the last administration. The average amount transferred from dam to fetus was 0.003% accumulated in the dam. In the fetus, the highest concentration was found in the fetal placenta followed by the liver, heart, skin, muscle, blood, lung, and brain. The PCBs level in fetal blood was the same as in maternal blood. The average concentration of PCBs in milk was 1.84 ppm. The amount transferred to sucklings increased gradually to about 5% of the maternal PCBs.