Interaction of spermine with polyphosphoinositide-containing liposomes and myo-inositol 1,4,5 trisphosphate

The interaction of spermine with liposomes containing 2% phosphatidylinositol, phosphatidylinositol 4 phosphate and phosphatidylinositol 4,5 biphosphate was inferred from the ability of these liposomes to interfere with spermine binding to the resin heparin-Sepharose. The inositol phospholipids test...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 135; no. 1; pp. 58 - 64
Main Authors Tadolini, B, Varani, E
Format Journal Article
LanguageEnglish
Published 01.01.1986
Subjects
liposomes
polyphosphoinositides
spermine
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Summary:The interaction of spermine with liposomes containing 2% phosphatidylinositol, phosphatidylinositol 4 phosphate and phosphatidylinositol 4,5 biphosphate was inferred from the ability of these liposomes to interfere with spermine binding to the resin heparin-Sepharose. The inositol phospholipids tested showed different affinities for spermine: the order of binding strength appear to be phosphatidylinositol, phosphatidylinositol 4 phosphate, phosphatidylinositol 4,5 bisphosphate. The ability of vesicles containing 2% polyphosphoinositides to interact with spermine is comparable to that of either single stranded RNAs or highly negatively charged liposomes. Myo-inositol 1,4,5 trisphosphate has a much lower ability to bind spermine.
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ISSN:0006-291X