Quantitative autoradiographic localization of the D sub(1) and D sub(2) subtypes of dopamine receptors in rat brain

The distribution of D sub(1) and D sub(2) receptors was studied in coronal sections of rat brain, using quantitative autoradiography. D sub(1) receptors were labeled with super(3)H-SKF-83566 (a brominated analog of super(3)H-SCH-23390), while D sub(2) receptors were labeled with super(3)H-spiroperid...

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Bibliographic Details
Published inThe Journal of neuroscience Vol. 6; no. 11; pp. 3177 - 3188
Main Authors Boyson, S J, McGonigle, P, Molinoff, P B
Format Journal Article
LanguageEnglish
Published 01.01.1986
Subjects
autoradiography
brain
dopamine D1
dopamine D2
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Summary:The distribution of D sub(1) and D sub(2) receptors was studied in coronal sections of rat brain, using quantitative autoradiography. D sub(1) receptors were labeled with super(3)H-SKF-83566 (a brominated analog of super(3)H-SCH-23390), while D sub(2) receptors were labeled with super(3)H-spiroperidol ( super(3)H-SPD). Sections of CPu mash were used in competition studies that confirmed that the specific binding of super(3)H-SKF-83566 was selective for D sub(1) receptors, and that the binding of super(3)H-SPD was selective for D sub(2) receptors. D sub(1) receptors were found throughout the forebrain and were present in greater density than were D sub(2) receptors in all regions examined except the olfactory nerve layer.
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ISSN:0270-6474