Diagnosis of a T-lineage acute lymphoblastic leukemia through digitalized cell analysis of the pleural effusion
INTRODUCTIONPleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. CASE PRESENTATIONWe report the atypical onset of T-lineage AL...
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Published in | International medical case reports journal Vol. 6; pp. 77 - 80 |
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Main Authors | , , , , , , , , , |
Format | Report |
Language | English |
Published |
01.01.2013
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Online Access | Get full text |
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Summary: | INTRODUCTIONPleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. CASE PRESENTATIONWe report the atypical onset of T-lineage ALL in a 31-year-old man. The patient was admitted to the emergency room due to lung failure; at that moment, the patient's initial blood count was normal; the chest X-ray radiography showed a massive pleural effusion and a thoracentesis was carried out. Routine investigations performed on the pleural fluid using a new technology system and digitalized cell analysis demonstrated infiltration by immature cells. Therefore, bone marrow aspirate and flow cytometry analyses were performed, leading to the diagnosis of T-lineage ALL. A cord blood transplantation procedure was performed at the first hematological remission following chemotherapy regimens. The patient died of septic shock. CONCLUSIONThe case we reported underlines the usefulness of using automated instruments to identify abnormal lymphoid cells in body fluids. |
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Bibliography: | ObjectType-Case Study-2 content type line 59 SourceType-Reports-1 ObjectType-Report-1 |
ISSN: | 1179-142X 1179-142X |
DOI: | 10.2147/IMCRJ.S49278 |