A Study on the Geophylogeny of Clinical and Environmental Vibrio cholerae in Kenya: e74829

Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya i...

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Published inPloS one Vol. 8; no. 9
Main Authors Kiiru, John, Mutreja, Ankur, Mohamed, Ahmed Abade, Kimani, Racheal W, Mwituria, Joyce, Sanaya, Robert Onsare, Muyodi, Jane, Revathi, Gunturu, Parkhill, Julian, Thomson, Nicholas
Format Journal Article
LanguageEnglish
Published 01.09.2013
Subjects
Vibrio cholerae
Kenya
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Summary:Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya isolated between 2005 and 2010. Some environmental and all clinical isolates mapped back onto wave three of the monophyletic seventh pandemic V. cholerae El Tor phylogeny but other environmental isolates were phylogenetically very distinct. Thus, the genomes of the Kenyan V. cholerae O1 El Tor isolates are clonally related to other El Tor V. cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently.
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ISSN:1932-6203
DOI:10.1371/journal.pone.0074829