Studies on rhodanese synthesis in bovine adrenocortical cells

The synthesis of adrenodoxin, a mitochondrial iron-sulfur protein required for adrenocortical steroidogenesis, is known to be regulated chronically by ACTH. Rhodanese, also a mitochondrial enzyme, is thought to be required for synthesis of iron-sulfur centers, such as those contained in adrenodoxin....

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 130; no. 1; pp. 407 - 411
Main Authors Boggaram, V, Horowitz, P, Waterman, M R
Format Journal Article
LanguageEnglish
Published 01.01.1986
Subjects
adrenal cortex
cattle
mitochondria
thiosulphate sulphurtransferase
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Summary:The synthesis of adrenodoxin, a mitochondrial iron-sulfur protein required for adrenocortical steroidogenesis, is known to be regulated chronically by ACTH. Rhodanese, also a mitochondrial enzyme, is thought to be required for synthesis of iron-sulfur centers, such as those contained in adrenodoxin. In this study it has been found that rhodanese synthesis and activity are not regulated by ACTH, under the same conditions whereby ACTH induces adrenodoxin synthesis. In addition, unlike adrenodoxin, rhodanese is found to be synthesized in the mature form rather than as a higher molecular weight precursor protein.
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SourceType-Scholarly Journals-1
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ISSN:0006-291X