Back Cover: Rational Design for Cooperative Recognition of Specific Nucleobases Using [beta]-Cyclodextrin-Modified DNAs and Fluorescent Ligands on DNA and RNA Scaffolds (Chem. Eur. J. 32/2013)

A binary fluorimetric method for DNA and RNA analysis is proposed based on the combination of two probes designed to work cooperatively. One is an oligonucleotide conjugate bearing a [beta]-cyclodextrin. The other is a small reporter ligand, which comprises linked molecules of a nucleobase-specific...

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Published inChemistry : a European journal Vol. 19; no. 32; p. 10764
Main Authors Futamura, Akika, Uemura, Asuka, Imoto, Takeshi, Kitamura, Yusuke, Matsuura, Hirotaka, Wang, Chun-Xia, Ichihashi, Toshiki, Sato, Yusuke, Teramae, Norio, Nishizawa, Seiichi, Ihara, Toshihiro
Format Journal Article
LanguageEnglish
Published 01.08.2013
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Summary:A binary fluorimetric method for DNA and RNA analysis is proposed based on the combination of two probes designed to work cooperatively. One is an oligonucleotide conjugate bearing a [beta]-cyclodextrin. The other is a small reporter ligand, which comprises linked molecules of a nucleobase-specific heterocycle and an environment-sensitive fluorophore. The reporter ligand recognizes a single nucleobase displayed in a gap on the target labeled with the conjugate, and the fluorophore moiety forms a luminous inclusion complex with nearby cyclodextrin. For more details see the Full Paper by S. Nishizawa, T. Ihara etal. on
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ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201390120