Receptor-mediated degradation of human growth hormone in rats adipocytes and cultured human lymphocytes (IM-9)

In cultured human lymphocytes (IM-9) and in isolated rat adipocytes human growth hormone is substrate for a receptor-mediated degradation. The application of different inhibitors suggests that the receptor-mediated degradation of growth hormone in these 2 cell types takes place in an acidified compa...

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Bibliographic Details
Published inMolecular and cellular endocrinology Vol. 41; no. 1; pp. 85 - 92
Main Authors Weyer, B, Sonne, O
Format Journal Article
LanguageEnglish
Published 01.01.1985
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Summary:In cultured human lymphocytes (IM-9) and in isolated rat adipocytes human growth hormone is substrate for a receptor-mediated degradation. The application of different inhibitors suggests that the receptor-mediated degradation of growth hormone in these 2 cell types takes place in an acidified compartment by an energy-requiring process and involving thiol groups.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0303-7207