Additivity and independence of neuroprotective effects of GABA sub(A) and GABA sub(B) receptor agonists in complete global cerebral ischemia

Neuroprotective effects of GABA sub(B) agonist baclofen and GABA sub(A) agonists THIP and muscimol are completely additive. GABA sub(A) and GABA sub(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effec...

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Published inBulletin of experimental biology and medicine Vol. 130; no. 2; pp. 772 - 774
Main Authors Kulinskii, VI, Mikhel'son, G V
Format Journal Article
LanguageEnglish
Published 01.08.2000
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Summary:Neuroprotective effects of GABA sub(B) agonist baclofen and GABA sub(A) agonists THIP and muscimol are completely additive. GABA sub(A) and GABA sub(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA sub(A) and GABA sub(B) antagonists separately and in combination is not below the estimated value. Therefore, GABA sub(A) and GABA sub(B) receptor mechanisms of the neuroprotective effects independently and separately contribute to the improvement of brain resistance to global ischemia.
Bibliography:ObjectType-Article-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/BF02681942