Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment. e66494

• Published in: PloS one Vol. 8; no. 6
• Main Authors: Jrad-Lamine, Aicha, Henry-Berger, Joelle, Damon-Soubeyrand, Christelle, Saez, Fabrice, Kocer, Ayhan, Janny, Laurent, Pons-Rejraji, Hanae, Munn, David H, Mellor, Andrew L, Gharbi, Najoua
• Format: Journal Article
• Language: English
• Published: 01.06.2013
• Subjects: Animal models
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0066494

The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1-/- model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1-/- animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.