Hb Marseille ( alpha sub(2) beta sub(2) N methionyl - 2 (NA sub(2)) His arrow right Pro): A new beta chain variant having an extended N-terminus

A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal beta chain, high pressure liquid chromatogr...

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Published inFEBS letters Vol. 178; no. 2; pp. 315 - 318
Main Authors Blouquit, Y, Arous, N, Lena, D, Delanoe-Garin, J, Lacombe, C, Bardakdjian, J, Vovan, L, Orsini, A, Rosa, J, Galactero, F
Format Journal Article
LanguageEnglish
Published 01.01.1984
Subjects
diabetes mellitus
hemoglobin Marseille
high-performance liquid chromatography
man
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Summary:A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal beta chain, high pressure liquid chromatography of the corresponding tryptic peptides and then microsequencing of the abnormal T sub(1). These procedures revealed a double abnormality: the presence of a methionyl residue extending the NH sub(2) terminus and a histidine to proline substitution in position NA sub(2).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0014-5793