DNA sequence and transcriptional organization of essential cell division genes ftsQ and FasA of Escherichia coli : Evidence for overlapping transcriptional units

The DNA sequence of a cloned segment of the Escherichia coli chromosome containing ftsQ, ftsA , and part of the ftsZ gene was determined and interpreted for genetic complementation and promoter fusion data for the region. The contiguous genes ftsQ, ftsA , and ftsZ were transcribed in the same direct...

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Published inJournal of bacteriology Vol. 160; no. 2; pp. 546 - 555
Main Authors Robinson, A C, Kenan, D J, Hatfull, G F, Sullivan, N F, Spiegelberg, R, Donachie, W D
Format Journal Article
LanguageEnglish
Published 01.01.1984
Subjects
Escherichia coli
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Summary:The DNA sequence of a cloned segment of the Escherichia coli chromosome containing ftsQ, ftsA , and part of the ftsZ gene was determined and interpreted for genetic complementation and promoter fusion data for the region. The contiguous genes ftsQ, ftsA , and ftsZ were transcribed in the same direction (clockwise on the genetic map) and each had at least one associated promoter which allowed it to be transcribed independently of neighboring genes. The observation that the termination codon of ftsQ overlaps with a potential initiation codon for ftsA suggested that these two genes may be translationally coupled when transcription is initiated upstream of the ftsQ coding sequence.
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ISSN:0021-9193