Association between an Alzheimers Disease-Related Index and APOE epsilon 4 Gene Dose. e67163
Background We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E epsilon 4 (APOE epsilon 4) gene...
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Published in | PloS one Vol. 8; no. 6 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.06.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Background We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E epsilon 4 (APOE epsilon 4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal epsilon 4 homozygotes, heterozygotes, and non-carriers. Methods An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 epsilon 4 homozygotes, 46 heterozygotes, and 78 non-carriers. Results These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001). Conclusions The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0067163 |