Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines

The authors describe a sequence of reciprocal interactions between cloned inducer T cells and antigen-presenting cells (APC) that results in selective depletion of the antigen-reactive inducer cells. It was shown that corecognition of antigen and I-A by hapten-reactive inducer T cell clones results...

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Published inThe Journal of experimental medicine Vol. 158; no. 3; pp. 1243 - 1258
Main Authors Rao, A, Faas, S J, Miller, L J, Riback, P S, Cantor, H
Format Journal Article
LanguageEnglish
Published 01.01.1983
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Summary:The authors describe a sequence of reciprocal interactions between cloned inducer T cells and antigen-presenting cells (APC) that results in selective depletion of the antigen-reactive inducer cells. It was shown that corecognition of antigen and I-A by hapten-reactive inducer T cell clones results in (a) release of macrophage-activating factor (MAF) and other lymphokines, (b) expression of lytic activity by a subset of MAF-sensitized APC after triggering, and (3) lysis (mediated by the activated and riggered macrophage) of the inducer T cell clone and other cells in the vicinity. It was suggested that this sequence of steps may limit the extent of macrophage-mediated tissue destructon by depleting the specific inducer T cell clones that initiate the response.
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ISSN:0022-1007