Malaria Control and the Intensity of Plasmodium falciparum Transmission in Namibia 1969-1992. e63350

• Published in: PloS one Vol. 8; no. 5
• Main Authors: Noor, Abdisalan M, Alegana, Victor A, Kamwi, Richard N, Hansford, Clifford F, Ntomwa, Benson, Katokele, Stark, Snow, Robert W
• Format: Journal Article
• Language: English
• Published: 01.05.2013
• Subjects: Plasmodium falciparum; Namibia
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0063350

Background Historical evidence of the levels of intervention scale up and its relationships to changing malaria risks provides important contextual information for current ambitions to eliminate malaria in various regions of Africa today. Methods Community-based Plasmodium falciparum prevalence data from 3,260 geo-coded time-space locations between 1969 and 1992 were assembled from archives covering an examination of 230,174 individuals located in northern Namibia. These data were standardized the age-range 2 to less than 10 years and used within a Bayesian model-based geo-statistical framework to examine the changes of malaria risk in the years 1969, 1974, 1979, 1984 and 1989 at 55 km spatial resolution. This changing risk was described against rainfall seasons and the wide-scale use of indoor-residual house-spraying and mass drug administration. Results Most areas of Northern Namibia experienced low intensity transmission during a ten-year period of wide-scale control activities between 1969 and 1979. As control efforts waned, flooding occurred, drug resistance emerged and the war for independence intensified the spatial extent of moderate-to-high malaria transmission expanded reaching a peak in the late 1980s. Conclusions Targeting vectors and parasite in northern Namibia was likely to have successfully sustained a situation of low intensity transmission, but unraveled quickly to a peak of transmission intensity following a sequence of events by the early 1990s.