Characteristics of a hemolysin from Gonyaulax monilata Howell

A toxic extract from the red tide dinoflagellate, Gonyaulax monilata Howell has been isolated. The hemolytic activity of the extract against human erythrocytes was compared, in vitro, to those of digitonin and phospholipase A sub(2). The hemolytic component of the toxic extract appears to cause frag...

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Published inAquatic toxicology Vol. 2; no. 1; pp. 15 - 22
Main Authors Bass, EL, Pinion, J P, Sharif, ME
Format Journal Article
LanguageEnglish
Published 01.01.1983
Subjects
biological poisons
erythrocytes
Gonyaulax monilata
hematology
hemolysins
human physiology
man
Marine
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Summary:A toxic extract from the red tide dinoflagellate, Gonyaulax monilata Howell has been isolated. The hemolytic activity of the extract against human erythrocytes was compared, in vitro, to those of digitonin and phospholipase A sub(2). The hemolytic component of the toxic extract appears to cause fragmentation of the erythrocyte membrane. It does not appear that hemolysis is caused by hydrolytic action on the lecithin fraction of the membrane. The active component exhibits chemical characteristics like those of an unsaturated glycolipid, possibly steroid based.
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SourceType-Scholarly Journals-1
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ISSN:0166-445X