Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligandsaPotential novel positron emitting tomography imaging agents

A series of novel TSPO ligands based on the tetracyclic class of translocator protein (TSPO) ligands first described by Okubo et al. was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved usi...

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Published inBioorganic & medicinal chemistry letters Vol. 23; no. 8; pp. 2368 - 2372
Main Authors OaShea, Dennis, Ahmad, Rabia, Aarstad, Erik, Avory, Michelle, Chau, Wai-Fung, Durrant, Clare, Hirani, Ella, Jones, Paul A, Khan, Imtiaz, Luthra, Sajinder K, Mantzilas, Dimitrios, Morisson-Iveson, Veronique, Passmore, Joanna, Robins, Edward G, Shan, Bo, Wadsworth, Harry, Walton, Sarah, Zhao, Yongjun, Trigg, William
Format Journal Article
LanguageEnglish
Published 15.04.2013
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Summary:A series of novel TSPO ligands based on the tetracyclic class of translocator protein (TSPO) ligands first described by Okubo et al. was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
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ISSN:0960-894X