CD4 super(+) Cutaneous T-Cell Lymphomas Show the Phenotype of Helper/Inducer T Cells (CD45RA super(-), CDw29 super(+))

CD4 super(+) T cells are heterogenous and include at least two subsets that differ in their influence to immunoglobin synthesis, cytokine secretion pattern and immunophenotype. Among others these subsets have been designated as suppressor/inducer or naive T cells (CD45RA super(+), CDw29 super(-)) an...

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Published inJournal of investigative dermatology Vol. 93; no. 3; pp. 413 - 416
Main Authors Sterry, Wolfram, Mielke, Volker
Format Journal Article
LanguageEnglish
Published 01.09.1989
Subjects
CD4 antigen
Cell activation
Cytokines
Dermatology
Immunoglobulins
Immunological memory
Interleukin 4
Lymphocytes T
Memory cells
Mycosis fungoides
Peripheral blood
Plasma cells
Skin
T-cell lymphoma
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Summary:CD4 super(+) T cells are heterogenous and include at least two subsets that differ in their influence to immunoglobin synthesis, cytokine secretion pattern and immunophenotype. Among others these subsets have been designated as suppressor/inducer or naive T cells (CD45RA super(+), CDw29 super(-)) and helper/inducer or memory T cells (CD45RA super(-), CDw29 super(+)). Current theories suggest that these CD4 super(+) T-cell subsets either reflect sequential stages of maturation before and after activation (antigen contact) or represent distinct lineages. In this study, we systematically analyzed the participation of both suppressor/inducer (CD45RA super(+)) and helper/inducer (CDw29 super(+)) T cells in the dermal lymphohistiocytic infiltrate of various CD4 super(+) cutaneous T-cell lymphomas. Although in peripheral blood both subsets are equally distributed, we present evidence that all CD4 super(+) cutaneous T-cell lymphomas are of the helper/inducer T cell phenotype. These findings are of importance both for pathogenetic and clinical considerations: the presence of plasma cells in dermal infiltrates and the elevation of serum immunoglobulins in patients of mycosis fungoides may be the consequence of interleukin-4 secretion of the neoplastic CD super(+) helper/inducer cells. The exclusive memory T cell phenotype of cutaneous T-cell lymphomas may be due to a general predominance of this subset in the skin, or be the consequence of cellular activation during malignant transformation.Journal of Investigative Dermatology (1989) 93, 413-416; doi:10.1111/1523-1747.ep12280303
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ISSN:0022-202X
DOI:10.1111/1523-1747.ep12280303