ECOGENETICS AND PHARMACOGENETICS: THE IMPORTANCE OF GENETIC POLYMORPHISMS IN THE VARIABILITY OF ORGANISMS RESPONSE TO ENVIRONMENTAL FACTORS

Genetics and genomics are certain to have a large impact in drug development and proper pharmaceutical treatment of subgroups of patients with many specific diseases. We should be able to increase the therapeutic margin for many agents. Genetic variation will also be important in refining estimates...

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Published inAnalele științifice ale Universității "Al. I. Cuza" din Iași. Serie nouă. Genetică și biologie moleculară Vol. 6
Main Authors Tudose, Cristian, Patras, Xenia, Tudose, Mihaela
Format Journal Article
LanguageEnglish
Published 01.01.2005
Subjects
Ale
Drug development
Drugs
Environmental factors
Gene polymorphism
Genetic diversity
genomics
Pharmaceuticals
Pharmacogenetics
pharmacogenomics
Public health
Side effects
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Summary:Genetics and genomics are certain to have a large impact in drug development and proper pharmaceutical treatment of subgroups of patients with many specific diseases. We should be able to increase the therapeutic margin for many agents. Genetic variation will also be important in refining estimates of risk from all kinds of environmental agents and in choosing more effective and more cost-effective risk reduction strategies. The linkage of information about genetic variation and information about environmental, nutritional, behavioral, metabolic, medical, and healthcare factors will be necessary to interpret the variation in clinical and public health terms. However, there is a great risk that present efforts toprotect confidentiality and privacy of individual genetic information may make such research infeasible. In the present paper we expose some general considerations about the importance of the borderline disciplines which are studying the cited aspects (ecogenetics, pharmacogenetics and pharmacogenomics), emphasising the importance of human populations genome polymorphisms affecting drug efficiency and producing adverse reactions; eventually we expose the most recent trends in pharmacogenomics related to the subject
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ISSN:1582-3571