QUANTIFICATION OF THE PROLIFERATIVE ACTIVITY IN THE EPITHELIAL TUMOURS OF THE OVARY

• Published in: Analele științifice ale Universității "Al. I. Cuza" din Iași. Serie nouă. Genetică și biologie moleculară Vol. 9; no. 1
• Main Authors: Francu, Laurian Lucian, Crauciuc, Eduard, Francu, Doina Lucia, Sorin, Andrei, Calin, Dorelia Lucia, Toma, Ovidiu
• Format: Journal Article
• Language: English
• Published: 01.01.2008
• Subjects: Ale; Benign; Evolution; Malignancy; Mitosis; Ovaries; Risk assessment; Risk factors; Risk groups; Tumors
• ISSN: 1582-3571

The diagnosis and the treatment of the ovarian tumors grading don't present always significant correlationswith the surviving chance. From this reason, the authors have proposed to study the proliferative activity in the maintypes of primitive epithelial tumors of the ovary (benign, borderline and malign) by computerized quantitative methodsand to establish the significance of the quantified parameters in establishing the degree of tumor risk. It was used aninteractive video digital quantitative program estimating the proliferative activity by stereological methods. The results were processed statistically and it was appreciated the degree of correlation with the tumor evolution. In the studied types of ovarian epithelial tumors, the proliferative activity represents an expressive indicator in establishing the malignancy degree. The comparative study of all types of EOT was allowed to establish some reference values for assessment of risk degree. The increase of mitotic activity index over 8 mitosis / 10 hpf represents a criterion of high-risk in borderline EOT, and over 30 mitosis / 10 hpf attests doubtlessly the malignancy. The index of the mitotic activity is a method which can be used in the routine examination of the epithelial tumors of the ovary, firstly because is significant, but and rapid and easy to apply.