Chapter 1 - Rabies Virus Transcription and Replication

Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNAaN complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P). We present molecula...

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Bibliographic Details
Published inAdvances in virus research Vol. 79; pp. 1 - 22
Main Authors Albertini, Aurelie AV, Ruigrok, Rob WH, Blondel, Danielle
Format Journal Article
LanguageEnglish
Published 01.01.2011
Subjects
Cofactors
Data processing
DNA-directed RNA polymerase
Genomes
Inclusion bodies
Nucleoproteins
Phosphoproteins
Rabies
Rabies virus
Replication
Reviews
RNA viruses
RNA-directed RNA polymerase
Transcription
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Summary:Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNAaN complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P). We present molecular, structural, and cellular aspects of RABV transcription and replication. We first summarize the characteristics and molecular biology of both RNA synthesis processes. We then discuss biochemical and structural data on the viral proteins (N, P, and L) and their interactions with regard to their role in viral transcription and replication. Finally, we review evidence that rabies viral transcription and replication take place in cytoplasmic inclusion bodies formed in RABV-infected cells and discuss the role of this cellular compartmentalization.
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ISSN:0065-3527
DOI:10.1016/B978-0-12-387040-7.00001-9