Aqueous-phase quantitative NMR determination of amino acid enantiomer ratio by super(13)C-NMR using chiral neodymium shift reagent

A neodymium-(S)-PDTA (PDTA = N,N,N',N'-tetrakis[(hydroxycarb onyl)methyl]-1,2-diaminopropane) complex was found exceptionally useful in the quantitative determination of enantiomer ratios of water-soluble natural amino acids by super(13)C-NMR. The method is demonstrated on mixtures of l- a...

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Bibliographic Details
Published inAmino acids Vol. 38; no. 5; pp. 1343 - 1350
Main Authors Florini, Nicola, Faglioni, Francesco, Zucchi, Claudia, Caglioti, Luciano, Palyi, Gyula
Format Journal Article
LanguageEnglish
Published 01.05.2010
Subjects
Amino acids
Enantiomers
Mathematical analysis
Molecular orbitals
Neodymium
Nuclear magnetic resonance
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Summary:A neodymium-(S)-PDTA (PDTA = N,N,N',N'-tetrakis[(hydroxycarb onyl)methyl]-1,2-diaminopropane) complex was found exceptionally useful in the quantitative determination of enantiomer ratios of water-soluble natural amino acids by super(13)C-NMR. The method is demonstrated on mixtures of l- and d-enantiomers of various amino acids. The interactions of the chiral shift reagent with the amino acid molecules were rationalized by molecular orbital calculations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-009-0341-9