Thyroid hormone controls carnitine status through modifications of [gamma]-butyrobetaine hydroxylase activity and gene expression

• Published in: Cellular and molecular life sciences : CMLS Vol. 59; no. 3; p. 540
• Main Authors: Galland, S, Georges, B, Le Borgne, F, Conductier, G, Viana Dias, J, Demarquoy, J
• Format: Journal Article
• Language: English
• Published: Basel Springer Nature B.V 01.03.2002
• Subjects: Bioavailability; Biosynthesis; Enzymes; Fatty acids; Gene expression; Hormones; Metabolism; Oxidation; Thyroid; Thyroid gland

The carnitine system plays a key role in β-oxidation of long-chain fatty acids by permitting their transport into the mitochondrial matrix. The effects of hypothyroidism and hyperthyroidism were studied on γ-butyrobetaine hydroxylase (BBH), the enzyme responsible for carnitine biosynthesis in the ra...