Unexpected Hemoglobin A^sub 1c^ Results/Commentary/Commentary

Immunoassays use antibodies that target N-terminal glycated amino acids on the β chain to quantify Hb A^sub 1c^, and the Hb A^sub 1c^ percentage is calculated from the Hb A^sub 1c^ and Hb concentrations (2). [...] any factor that prevents glycation or any mutation in the epitope of the N-terminal a...

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Bibliographic Details
Published inClinical chemistry (Baltimore, Md.) Vol. 57; no. 2; p. 153
Main Authors Sofronescu, Alina-Gabriela, Williams, Laurie M, Andrews, Dorinda M, Zhu, Yusheng, Little, Randie R, Fisher, Simon J
Format Journal Article
LanguageEnglish
Published Washington Oxford University Press 01.02.2011
Subjects
Amino acids
Blood
Colleges & universities
Conflicts of interest
Diabetes
Immunoassays
Laboratories
Mass spectrometry
Methods
Monitoring systems
Mutation
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Summary:Immunoassays use antibodies that target N-terminal glycated amino acids on the β chain to quantify Hb A^sub 1c^, and the Hb A^sub 1c^ percentage is calculated from the Hb A^sub 1c^ and Hb concentrations (2). [...] any factor that prevents glycation or any mutation in the epitope of the N-terminal amino acids that affects antibody recognition will produce erroneous results.
ISSN:0009-9147
1530-8561