Optogenetic experimentation on astrocytes

We briefly review the current literature where optogenetics has been used to study various aspects of astrocyte physiology in vitro and in vivo. This includes both genetically engineered Ca2+ sensors and effector proteins, such as channelrhodopsin. We demonstrate how the ability to target astrocytes...

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Bibliographic Details
Published inExperimental physiology Vol. 96; no. 1; p. 40
Main Authors Figueiredo, M, Lane, S, Tang, F, Liu, B. H, Hewinson, J, Marina, N, Kasymov, V, Souslova, E. A, Chudakov, D. M, Gourine, A. V, Teschemacher, A. G, Kasparov, S
Format Journal Article
LanguageEnglish
Published Oxford John Wiley & Sons, Inc 01.01.2010
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Summary:We briefly review the current literature where optogenetics has been used to study various aspects of astrocyte physiology in vitro and in vivo. This includes both genetically engineered Ca2+ sensors and effector proteins, such as channelrhodopsin. We demonstrate how the ability to target astrocytes with cell-specific viral vectors to express optogenetic constructs helped to unravel some previously unsuspected roles of these inconspicuous cells.
ISSN:0958-0670
1469-445X