UNVEILING THE ROLE OF TRANSPOSABLE ELEMENT EXPRESSION AFTER INFESTATION WITH INFECTIOUS PANCREATIC NECROSIS VIRUS IN ATLANTIC SALMON

Transposable elements (TEs) are remnants of ancient viral infections and make up substantial proportions of eukaryotic genomes. Current research has begun to highlight the role TEs can play in the immune system's response to infections. However, most of our knowledge about TE expression during...

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Bibliographic Details
Published inBAG. Journal of basic and applied genetics Vol. 35; p. 1
Main Authors Vidal, R, Moya, J, Guzman, O, Hinostroza, F, Güttler, V
Format Journal Article
LanguageEnglish
Published Buenos Aires Sociedad Argentina de Genetica 01.10.2024
Subjects
Homology
Immune response
Infections
Infectious pancreatic necrosis
Kidneys
Necrosis
Pancreas
Salmonidae
Transcriptomes
Transcriptomics
Transposons
Viral infections
Viruses
Online AccessGet full text
ISSN1666-0390
1852-6233

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Summary:Transposable elements (TEs) are remnants of ancient viral infections and make up substantial proportions of eukaryotic genomes. Current research has begun to highlight the role TEs can play in the immune system's response to infections. However, most of our knowledge about TE expression during infection comes from model organisms making it difficult to develop broader patterns regarding the role of TEs during infection. Therefore, in this work, we explore and characterize the potential contribution of transposable elements (TEs) to the immune response of Atlantic salmon (Salmo salar), subject to infectious pancreatic necrosis virus (IPNV) infections. IPNV is a highly pathogenic virus that affects the aquaculture of salmonids and can cause huge mortality rates. A de novo and homology-based identification of consensus TEs was performed using genomic and transcriptomic data of challenged-IPNv organism with and controls. Besides, a 2-step computational approach, consisting of identifying TEs in the proximity of key-responsive genes, followed by searching for cis-regulatory motifs in these TE sequences and linking them to known regulatory factors was developed. Head kidney transcriptome profiling revealed significant TE transcript differentiation among controls and challenged organisms associated with Class II TEs, such as PiggyBac, MITE and CRYPTON. Likewise, Class I, such as LINE, TLR and SINE also were identified. Our findings shed light on the role of TEs in the immune response to viral infections in salmonids.
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ISSN:1666-0390
1852-6233