Nigella sativa 3% Inhibition Test of Natural Toothpaste Compared Cetylpyridinum chloride (CPC) Toothpaste 0.01-0.1% on Aggregatibacter actinomycetemcomitans

• Published in: Indonesian Journal of Tropical and Infectious Disease Vol. 11; no. 3; p. 224
• Main Authors: Setiawatie, Ernie Maduratna, Widiyanti, Prihartini, Retno Puji Rahayu, Eprilina, Alifiani, Sandrasari, Desi, Savitri, Irma Yosephina, Bargowo, Lambang, Rihandhita, Shinta Meiliana
• Format: Journal Article
• Language: English
• Published: Surabaya Universitas Airlangga 01.01.2023
• Subjects: Gum disease; Toothpaste
• ISSN: 2085-1103; 2356-0991
• DOI: 10.20473/ijtid.v11i3.46075

Periodontitis generally begins with gingivitis progresses to alveolar bone increasing the risk of systemic disease. The primary etiological factor in the etiology of periodontal disease is Aggregatibacter actinomycetemcomitans bacteria. Cetylpyridinium chloride (CPC) has a bactericidal effect by disrupting the function of bacterial membranes in the cytoplasm. CPC can also absorb negative charges from bacteria, increase bacterial cell wall permeability, decrease cell metabolism, and reduce bacterial attachment to teeth. Use of antimicrobial toothpaste, such as Cetylpyridinium chloride (CPC), is one strategy to prevent periodontal disease, but CPC is hazardous in some quantities. As a result, it should be compared to a natural toothpaste, specifically Nigella sativa toothpaste. The objective of this study is to compare the antibacterial activity of natural toothpaste containing Nigella sativa 3% with toothpaste containing CPC 0.01% - 0.1% on Aggregatibacter actinomycetemcomitans. Experimental studies are used in this kind of research. The colony count method was used to assess the natural toothpastes Nigella sativa 3% and toothpaste containing CPC 0.01- 0.1% for their capacity in inhibiting the Aggregatibacter actinomycetemcomitans. Natural toothpaste containing Nigella sativa 3% was completely inhibiting Aggregatibacter actinomycetemcomitans, compared to 0.01-0.1% CPC toothpaste. The significance level for the statistical test results was 0.000 (p<0.05). The conclusion of this research are the natural toothpaste containing Nigella sativa 3% and toothpaste containing CPC 0.06%–0.1% can effectively suppress the growth of the microorganisms Aggregatibacter actinomycetemcomitans.